Available data concerning the detection of human papillomavirus (HPV) DNA in cutaneous lesions of renal transplant recipients (RTRs) are conflicting.1-3
The aim of this study was to evaluate the spectrum of HPV types in cutaneous lesions from RTRs with a method capable of detecting a wide range of different HPVs.
Material and Methods
The study was performed on paraffin-embedded tissue from 184 skin biopsy specimens corresponding to 64 RTRs and 43 immunocompetent patients (ICPs). The biopsy specimens from RTRs included 70 verrucae vulgaris (VV), 30 precancerous keratoses, 30 basal cell carcinomas, and 11 squamous cell carcinomas. The biopsy specimens from ICPs consisted of 20 VV, 5 precancerous keratoses, 8 basal cell carcinomas, and 10 squamous cell carcinomas.
Two 5-µm-thick sections from each specimen were obtained under sterile conditions and then processed as recommended in the protocol supplied with the HPV kit (HPV Fast Kit, Pharma Gen SA, Madrid, Spain). This polymerase chain reaction . . . [Full Text of this Article]
Results
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