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Infective Dermatitis
A Pabulum for Human T-Lymphotrophic Virus Type I Leukemogenesis?
Arch Dermatol. 1998;134:487-488.
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ALTHOUGH THE history of animal retroviruses dates back to the beginning of the century, the first pathogenic human retrovirus was discovered only 18 years ago. In 1980, Poiesz and coworkers1 isolated a novel retrovirus from the lymphocytes of 2 patients who were diagnosed as having cutaneous T-cell lymphoma and Sézary syndrome. The same virus was isolated independently from a Japanese patient with leukemia by Miyoshi et al2 in 1981. Since both viruses were indistinguishable by nucleic acid comparison, the name human T-lymphotrophic virus type I (HTLV-I) was proposed3 for all isolates previously called adult T-cell leukemia virus in Japan and HTLV in the United States.
In the years after the isolation of the virus, multiple epidemiological and molecular studies confirmed that HTLV-I infection was associated with adult T-cell leukemia/lymphoma (ATL), an aggressive fatal T-cell neoplasm found in Japan, the Caribbean Islands, central Africa, and geographical areas where inhabitants of those . . . [Full Text of this Article]
RELATED ARTICLE
Clinical, Pathologic, and Immunologic Features of Human T-Lymphotrophic Virus Type I–Associated Infective Dermatitis in Children
Lois La Grenade, Angela Manns, Valerie Fletcher, Christine Carberry, Barrie Hanchard, Elizabeth M. Maloney, Beverley Cranston, Nadia P. Williams, Rainford Wilks, Eric Choo Kang, and William A. Blattner
Arch Dermatol. 1998;134(4):439-444.
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