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Itraconazole as a New Treatment for Pustulosis Palmaris et Plantaris
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Pustulosis palmaris et plantaris (PPP) is a common skin disease that is difficult to treat. We describe 7 patients with PPP in whom the oral administration of itraconazole proved highly effective.
Report of Cases
The clinical data of 7 patients are summarized in Table 1. The patients included 3 men and 4 women ranging in age from 40 to 62 years at the start of administration of itraconazole. The duration of disease before administration of the drug ranged from 7 months to 30 years. All patients started to take itraconazole, 100 mg/d, as an initial dosage and the maintenance dosages were 50 mg/d in 4 patients and 100 mg/d and 50 mg/d alternately in 2 patients. Patient 7 continued to take the initial dosage of 100 mg/d for 6 months without changing to the maintenance dosage. The follow-up periods ranged from 4 weeks to 2 years. In all patients, pustules on the . . . [Full Text of this Article] Comment
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