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Human Herpesvirus 6 Infection in Patients With Exanthema After Allogeneic Bone Marrow Transplantation
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Frequent reactivation of human herpesvirus 6 (HHV-6) has been demonstrated in immunocompromised patients after renal or bone marrow transplantation (BMT). Using polymerase chain reaction (PCR), HHV-6 DNA has been detected in exanthematous skin after BMT,1 as well as in skin and/or rectal biopsy specimens of patients without exanthema prior to undergoing BMT.2 One study showed that after allogeneic BMT there is an increased risk of developing graft-vs-host disease, in which HHV-6 DNA is found in rectal and/or skin biopsy specimens.2 To investigate a pathogenic role of HHV-6 reactivation during cutaneous exanthema after allogeneic BMT, we determined HHV-6 DNA levels using quantitative PCR in blood and simultaneously in both erythematous and normal skin biopsy specimens.
Thirteen patients presenting with cutaneous exanthema following allogeneic BMT were studied prospectively. Patients found to have cytomegalovirus viremia via a cell culture were excluded. No patient was infected with human immunodeficiency virus 1 or human immunodeficiency . . . [Full Text of this Article]
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Human Herpesviruses 6 and 7: New Roles Yet to Be Discovered?
Le Cleach et al.
Arch Dermatol 1998;134:1155-1157.
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