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Recurrent erythema multiforme (REM) is a mucocutaneous disorder induced by recurrent herpes simplex virus (HSV) infection in 70% of cases.¹ Herpes simplex virus genome was detected using the polymerase chain reaction in active REM lesions and in pigmented marks several weeks after healing of the lesions.² Preventive treatment with oral acyclovir, usually 400 mg twice per day, completely suppresses REM attacks in most patients.³ It is not clear whether failures of acyclovir are related to viral resistance to acyclovir or to non-HSV–induced REM. For the first time, we report a case of postherpetic REM resistant to continuous acyclovir treatment but responsive to the new drug valacyclovir hydrochloride.

Report of a Case

A 27-year-old human immunodeficiency virus–seronegative highly educated man had nasal herpetic recurrences since the age of 12 years. We saw him for the first time in 1993 for an episode of recurrent nasal herpes, followed 6 days later by fever, bilateral conjunctivitis, large . . . [Full Text of this Article]

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