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Lessons From Metastases

Arch Dermatol. 1998;134:1027-1028.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

MELANOMA, a common and serious disease encountered by dermatologists, has several unique features. Three questions of concern to the dermatologist are as follows: First, what is the difference between radial and vertical growth melanoma in terms of biology? Second, why does the prognosis of melanoma significantly worsen when the lesion becomes greater than 0.75 mm in thickness? Finally, how can the phenomenon of metastasis years and even decades after initial resection be explained? The article by Barnhill et al¹ teaches us some basic lessons about the behavior of melanoma, lessons that may be useful in answering these 3 questions about melanoma.

While increased rates of cell proliferation account for in vivo growth of tumors, the mechanisms by which tumors stop growing in animals have only recently been explained. Current evidence based on experiments in mice reveal that there are 2 reasons why tumors do not grow in vivo, or become . . . [Full Text of this Article]

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