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Analysis of p53 Gene Mutations in Keloids Using Polymerase Chain Reaction–Based Single-Strand Conformational Polymorphism and DNA Sequencing—Clinical Implications
Bruce Smoller, MD
Little Rock, Ark
Arch Dermatol. 1998;134:967.
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MUTATIONS of p53 have been implicated in a wide range of neoplasms. It is generally believed that mutations in this tumor suppressor gene lead to the uncontrolled proliferation of cells and dysregulation of apoptosis. In the present study, Saed et al found similar mutations in all of the keloids they examined. This observation raises several biologic questions and provides possible direction for future therapeutic intervention. The finding of increased p53 mutations within these lesions may explain the dysregulated repair sequence followed by the fibroblasts in this condition. However, this finding also raises questions about the role of p53 in neoplasia in general and malignancy in particular. While keloids are known to be locally aggressive neoplasms, they are not known to metastasize. Thus, in this situation, it appears that p53 mutations may play a role in stimulating or permitting local growth, but are not sufficient to allow neoplasms . . . [Full Text of this Article]
RELATED ARTICLE
Analysis of p53 Gene Mutations in Keloids Using Polymerase Chain Reaction–Based Single-Strand Conformational Polymorphism and DNA Sequencing
Ghassan M. Saed, Daniel Ladin, Jennifer Olson, Xuefei Han, Zizheng Hou, and David Fivenson
Arch Dermatol. 1998;134(8):963-967.
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