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Toxic Eruption in a Woman With Chronic Arthritis
Kelly L. Abate, MD;
Frederick D. Malkinson, MD
Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill
Arch Dermatol. 1999;135:81-86.
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REPORT OF A CASE
A 47-year old woman presented with a 5-day history of an erythematous, mildly pruritic, vesicular eruption on her trunk and extremities. She reported a several-year history of arthritis of the large and small joints and nightly fevers, with temperatures as high as 39.4°C, the week before her cutaneous eruption developed. The findings of a thorough review of her systems were otherwise unremarkable.
Her primary care physician had begun an exhaustive workup for connective tissue disease as a possible cause of her arthritis. Multiple nonsteroidal anti-inflammatory agents, including oxaprozin (Daypro), had been administered for arthritis relief over the course of the preceding years. Oxaprozin therapy was again initiated for symptomatic relief 2 weeks before the patient presented to the dermatology department.
On physical examination, it appeared that the patient was in no acute distress. Skin examination revealed coalescing erythematous papules and plaques disseminated . . . [Full Text of this Article]
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