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With respect to the observation by Kano et al¹ on cellular and molecular dynamics in exercise-induced urticarial vasculitis lesions, and to the editorial by Mehregan,² we would like to offer the following comments.

In their observation, Kano et al note that eosinophil was the first cell type that appeared around vessels in the induced lesion of urticarial vasculitis when intense expression of E-selectin was noted on endothelial cells. E-selectin is a molecule implicated in the initial adhesion of neutrophils, eosinophils, basophils, and memory T cells.³ Mehregan suggests that the expression of adhesion molecules found by Kano et al is similar to the findings that we reported in a study undertaken to investigate the sequential expression of adhesion molecules on endothelial and infiltrating inflammatory cells in 42 lesions of cutaneous leukocytoclastic vasculitis of between 24 and 72 hours' duration.⁴ In this study we observed that E-selectin expression on activated endothelium was . . . [Full Text of this Article]