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Acrocyanosis is either idiopathic or secondary to diseases such as myeloproliferative disorders.¹ It has been observed in patients infected with human immunodeficiency virus (HIV) together with cryoglobulinemia² and Pneumocystis carinii septicemia.³ Here we report a case of an HIV-infected patient with acrocyanosis secondary to abuse of butyl nitrite. This is the first report of this adverse effect.

Report of a Case

During a 10-day period, a 28-year-old patient with HIV infection, stage A3 according to the classification of the Centers for Disease Control and Prevention, experienced increasing, painless, livid to gray bluish macules (Figure 1) with underlying edematous swelling of the nose, ears, and back of the hands in a symmetrical pattern without other symptoms such as fever or dizziness. After a detailed anamnesis, the patient reported daily inhalation of butyl nitrite for several minutes over the last 2 weeks. Use of other vasoactive agents like - and -adrenergic blocking agents or . . . [Full Text of this Article]

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