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The challenge of cutaneous adverse drug reactions for the consultant dermatologist is in determining a specific etiologic agent, especially in the setting of polypharmacy. The risk of reexposure to individual medications usually outweighs the benefits, especially in the case of severe drug eruptions. Recently, patch testing has been advocated as a potentially useful test in some severe cutaneous adverse drug reactions, especially acute generalized exanthematous pustulosis (AGEP).¹

Metronidazole, an oral synthetic antiprotozoal and antibacterial agent, has been implicated as a cause of AGEP,² but the patient described in that study was also taking cefazolin, and no confirmatory testing was performed. We report a case of metronidazole-induced AGEP where subsequent patch testing results were positive.

Report of a Case.

A 41-year-old man with no personal or family history of psoriasis was admitted to the Hospital of Saint Raphael with fever and a pustular rash. He had been taking metronidazole, 250 mg, 3 times daily for . . . [Full Text of this Article]

Comment.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Systemic Reaction to Patch Testing for the Evaluation of Acute Generalized Exanthematous Pustulosis
Mashiah and Brenner
Arch Dermatol 2003;139:1181-1183.
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