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Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine with multiple functions. It is produced by T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts. Dranoff et al¹ were the first to show the antitumor reactivity in B16 mice following active immunization with B16 melanoma cells transfected with the GM-CSF gene. Granulocyte-macrophage colony-stimulating factor has also been reported to accelerate pressure ulcer healing, and regression of metastatic carcinoma in skin appendages.^2-3 Recently, Leong et al⁴ demonstrated that autologous tumor vaccine with local recombinant human GM-CSF (rhGM-CSF) injections resulted in tumor regression in patients with stage IV melanoma.

Report of a Case

An 83-year-old white woman presented with a medical history of squamous cell carcinoma, solar keratosis, and melanoma in situ of the right upper eyelid. When the patient was first seen at the University of California, San Francisco, Melanoma Center on July 28, 1997, a 2-cm brown to black, irregular-bordered plaque of the . . . [Full Text of this Article]

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