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Hepatitis C Virus–Related Skin Diseases
Arch Dermatol. 1999;135:1401-1403.
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THE HEPATITIS C virus (HCV) was identified 10 years ago thanks to research in molecular biology.1 At present, HCV infection is a major public health problem in many countries, with the worldwide prevalence of HCV markers ranging from from 0.1% to 5% (including 150 million chronic carriers). Infection becomes chronic in 70% to 80% of cases and is complicated by cirrhosis within 20 years of contamination in about 20% of them. Once the cirrhotic process has begun, the incidence of hepatocellular carcinoma ranges from 1% to 4%. Factors leading to more severe liver injury include excessive alcohol comsumption, older age at the time of initial infection, immunosuppression, and specific genotypes. During the course of HCV infection, many extrahepatic manifestations have been reported.2
IS THIS VIRUS CAPABLE OF INDUCING CUTANEOUS DISEASES?
YES, CERTAINLY.
Hepatitis C viral infection is clearly involved in cases of mixed cryoglobulinemia (MC) and porphyria cutanea tarda (PCT). Recent evidence has incriminated HCV in many cases that, in . . . [Full Text of this Article] Yes, Probably. Yes, Perhaps.
HOW DOES THE VIRUS ACT?
HOWEVER, WHY DO THESE SIGNS APPEAR ONLY IN CERTAIN PATIENTS?
Viral Genotypes?
Viral Load? Genetic Predisposition of the Host? Coinfections With Other Viruses?
RELATED ARTICLE
Chronic Urticaria Is Not Significantly Associated With Hepatitis C or Hepatitis G Infection: A Case-Control Study
Bernard J. Cribier, Frédéric Santinelli, Carine Schmitt, Françoise Stoll-Keller, and Edouard Grosshans
Arch Dermatol. 1999;135(11):1335-1339.
ABSTRACT
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