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Minocycline Hypersensitivity With Respiratory Failure
Beth D. Clayton, MD;
Michael G. Hitchcock, MBChB;
Phillip M. Williford, MD
Arch Dermatol. 1999;135:139-140.
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REPORT OF A CASE
A previously healthy 26-year-old white woman developed headache, fever, and malaise during a 2-week period. She was evaluated by her primary care physician, who gave her azithromycin for a presumed bacterial infection. She had started taking oral minocycline hydrochloride for acne vulgaris 2 weeks prior to development of symptoms. Her only other recent medications included oral contraceptives and tetracycline hydrochloride, which she had been taking for several months. During the next week, she developed a generalized erythematous eruption and intractable nausea and vomiting. She presented to the local emergency department and was admitted to the hospital, where she went into respiratory distress requiring intubation and mechanical ventilation. Prior to transfer to the intensive care unit at our institution, she suffered 2 brief, generalized tonic, clonic seizures. An infectious cause was suspected initially. Hepatitis A, B, and C and . . . [Full Text of this Article]
DIAGNOSTIC CHALLENGE
COMMENT
Wake Forest University, School of Medicine, Winston-Salem, NC
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Relapsing Acute Respiratory Failure Induced by Minocycline
Oddo et al.
Chest 2003;123:2146-2148.
ABSTRACT
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