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Blei et al¹ reported the rare familial occurrence of hemangiomas and/or vascular malformations in 6 kindreds. The vascular lesions appeared to be transmitted in an autosomal dominant fashion with moderate to high penetrance.

In 283 patients with port-wine stains attending a laser clinic, we studied the family history of birthmarks.² We were surprised to find that 72 patients (25.4%) had a family history of birthmarks, and 42 (15%) had a family history of vascular birthmarks; 20 of those were strawberry hemangiomas and 22 (7%) were port-wine stains. The figures for port-wine stains are higher than expected from the prevalence in the population, and our patients, like those in the study by Blei et al,¹ had vascular malformations and hemangiomas present in different members of the same family.

We congratulate Blei et al on their important observations, and we entirely agree with their advice that physicians caring for children with hemangiomas . . . [Full Text of this Article]

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