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Arch Dermatol. 1999;135:325-327.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of the ARCHIVES, Burden et al¹ compare the risk factors and the prognosis in a large sample of patients with multiple melanomas and in controls with a single melanoma. They also test the hypothesis of a possible link between CDKN2A mutations and the multiplicity of melanomas in the same patient.

Patients with multiple primary melanoma (MPM) are the individuals who have already developed successively or concomitantly several primary melanomas. This definition needs, however, several comments. Multiple melanoma should be distinguished from melanoma with metastases and melanoma with atypical nevi. This statement may appear useless, but the differential diagnosis is probably more confusing than expected. First, there is no reliable criterion to separate MPMs from a melanoma with an epidermotropic metastasis.² Second, the differential diagnosis between benign melanocytic lesions and melanomas is probably a source of bias for the inclusion in multiple melanoma series. After a melanoma diagnosis, . . . [Full Text of this Article]

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RELATED ARTICLE

Genetic and Environmental Influences in the Development of Multiple Primary Melanoma
A. David Burden, John Newell, Nicola Andrew, Gina Kavanagh, J. Michael Connor, and Rona M. MacKie
Arch Dermatol. 1999;135(3):261-265.
ABSTRACT | FULL TEXT