This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with great interest the case report of Downs and Kennedy¹ about the successful treatment of intractable palmoplantar pruritus with ondansetron. Because of our continuous research on pruritus and the action of serotonin type 3 (5-HT3) receptor antagonists, we think that there are major points that should be clarified.

First of all, palmoplantar pruritus is an unusual location and a descriptive term but is not a diagnostic and disease entity. This raises the question on the etiology of palmoplantar pruritus. According to the report, neurological examinations, including electroneurography and upper spine radiography, had not been performed. It is possible that the palmoplantar pruritus was caused by nerve compression, nerve alteration, or neuropathy. The report further lacks important information such as the occupation and hobbies of the patient, to rule out external factors. The medical history does not mention the patient's prior external medications. Elderly patients often use vasoactive emollients . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?