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Cribier et al¹ compared the presence of periungual erythema in 155 human immunodeficiency virus (HIV)–positive patients and 103 HIV-negative controls. Fingers were examined on only 1 occasion. Periungual erythema was found in 16 (10.3%) of the HIV-positive group and in 5 (4.9%) of the HIV-negative group (P=.08). The authors conclude: " . . . the frequency of this symptom [periungual erythema] was not significantly higher than in the control subjects . . . red fingers are not specific of either HIV or HCV [hepatitis C virus] infection."

This statement is not accurate for 2 reasons. First, a patient with only a single incident of periungual erythema without telangiectasia does not meet the criteria of "red fingers syndrome" which was defined only as a chronic, painless, well-delimited, and striking distal erythema of the fingers and the toes with multiple periungual telangiectasia. All symptoms must be present at least 1 . . . [Full Text of this Article]

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