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Enk and Knop¹ recently reported in the ARCHIVES the impressive results of treating pemphigus vulgaris with a combination of massive doses of prednisolone and mycophenolate mofetil. Two months after treating a flare in the activity of this disease in 12 patients with this combination of drugs, 9 of the patients were clinically free of disease, and all 9 remained free of disease during the ensuing year. This remission rate is much higher than expected with conventional therapy, which is normally associated with a 10% to 20% remission rate per year.² From this, the authors conclude that mycophenolate is highly effective in the treatment of pemphigus. But is it?

In fact, all patients were treated with 2 medications: a drug known to be effective for the treatment of pemphigus (prednisolone); and another of unknown effectiveness (mycophenolate). The prednisolone was used in a massive dose of 2 mg/kg per day, equivalent to . . . [Full Text of this Article]

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