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Finasteride in a 1-mg Dose Is Safe and Effective
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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As an investigator and contributing author of studies on finasteride and male pattern hair loss,1 I am writing in response to the commentary by Frankel2 published in the March 1999 issue of the ARCHIVES. In his commentary, Frankel raises concerns about the dosage, long-term adverse effects, and costs of Propecia (finasteride, 1 mg). It is appropriate to raise and publish opinions about controversial issues. Commentaries, however, are not held to the same rigorous scrutiny and high scientific standards as peer-reviewed articles.
Frankel asserts that the 1-mg dose is unnecessarily high and, therefore, unnecessarily expensive, arguing instead that the data would support a lower 0.2-mg dose. His conclusion about the appropriate dosage, based on data from a 6-week trial examining the effects of finasteride on serum and scalp dihydrotestosterone (DHT), is erroneous. A separate 6-month clinical dose-ranging study was specifically performed to assess the effects of finasteride on hair growth using . . . [Full Text of this Article]
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