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Erythematous Nodule on the Nail Bed
Sharon Horton, MD;
Richard Mizuguchi, MD;
Ali Moiin, MD;
Ken Hashimoto, MD
Wayne State University, Detroit, Mich
Arch Dermatol. 1999;135:1113-1118.
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REPORT OF A CASE
A 32-year-old white woman presented with a 2-year history of nail loss. She initially had noted a "small bump" on the corner of her right thumbnail. In time, the bump grew larger and split the nail, and, finally, a portion of the right thumbnail fell off. Occasionally, the patient experienced pain in the affected area of her thumb. Her medical history was noncontributory.
Cutaneous examination revealed a 7-mm erythematous nodule located on the lateral aspect of the right thumb, with the loss of one third of the lateral nail plate (Figure 1). An x-ray film of the thumb showed no evidence of bone abnormality. A biopsy specimen was obtained (Figure 2).
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Figure 1.
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Figure 2.
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What is your diagnosis?
Diagnosis: Amelanotic subungual melanoma.
The surface epithelium was irregularly acanthotic, with extensive proliferation of atypical melanocytic cells at the . . . [Full Text of this Article]
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