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In their review entitled "Dermatological Uses of High-Dose Intravenous Immunoglobulin," Jolles et al¹ did not mention the experience with such treatment in lupus erythematosus (LE). We report a case in which antimalarial-resistant cutaneous LE (CLE) was treated successfully with high-dose intravenous immunoglobulin.

Report of a Case

A diagnosis of subacute and acute CLE was made in a 30-year-old woman in August 1995. The patient presented with both purpuric lesions suggestive of vasculitis and photosensitive annular erythematous lesions suggestive of CLE. Histologically, basal cell layer damage with vacuolization was found; the results of direct immunofluorescence were negative. There were no clinical manifestations suggestive of systemic LE, and there was no hypocomplementemia or proteinuria. The white blood cell count was 3.4x10⁹/L and the platelet count was 128x10⁹/L. The results of antinuclear antibody testing were negative, but anti-SSA antibodies were present. From August 1995 to January 1997, therapy with topical clobetasol . . . [Full Text of this Article]

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