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Arch Dermatol. 2000;136:67.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this time of very tight funding for basic and clinical research, there is one issue that, although largely subliminal and unarticulated in our collective consciousness, ought to be addressed. It is the question of support for novel but potentially important ideas that reach beyond the boundaries of currently fashionable theory and challenge, or at least radically stretch, existing paradigms.

There has always been the obvious justification to give highest priority to emerging areas of current scientific interest and to exploit all the well-established technologies of the day. Furthermore, there are an increasing number of talented and well-trained scientists who are eager to contribute and to "fill in the details." A good example is the current explosion of information on the molecular abnormalities underlying an increasing number of cutaneous genetic disorders. Yet we should remember that virtually all of this proliferation of data rests on the earlier imaginative development of . . . [Full Text of this Article]