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  Vol. 136 No. 10, October 2000 TABLE OF CONTENTS
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KH 1060 for the Treatment of Lichen Planus: A Multicenter, Randomized, Double-blind, Vehicle-Controlled Study

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The treatment of lichen planus (LP) is often controversial and the results, disappointing.1 Most studies are of small series, with only a minority of controlled studies. We compared a new vitamin D3 analog (KH 1060) with the vehicle in the treatment of LP in a prospective, randomized, double-blind, vehicle-controlled, parallel group study. KH 1060 has been shown to inhibit cell proliferation, to induce cell differentiation, and to have a suppressive effect on T-cell activation.2-4

Patients and Methods

The patients recruited had a clinical and histologic diagnosis of LP. Exclusion criteria are given in Table 1. After a washout period of 2 weeks, the patients received twice daily for 8 weeks either KH 1060 (n = 49) or the vehicle (n = 43). The mean age of patients (50.2 years), mean duration of LP (2.0 years), and severity of the disease were similar in the 2 groups. After 2, 4, 6, and 8 . . . [Full Text of this Article]


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