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KH 1060 for the Treatment of Lichen Planus: A Multicenter, Randomized, Double-blind, Vehicle-Controlled Study
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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The treatment of lichen planus (LP) is often controversial and the results, disappointing.1 Most studies are of small series, with only a minority of controlled studies. We compared a new vitamin D3 analog (KH 1060) with the vehicle in the treatment of LP in a prospective, randomized, double-blind, vehicle-controlled, parallel group study. KH 1060 has been shown to inhibit cell proliferation, to induce cell differentiation, and to have a suppressive effect on T-cell activation.2-4
Patients and Methods
The patients recruited had a clinical and histologic diagnosis of LP. Exclusion criteria are given in Table 1. After a washout period of 2 weeks, the patients received twice daily for 8 weeks either KH 1060 (n = 49) or the vehicle (n = 43). The mean age of patients (50.2 years), mean duration of LP (2.0 years), and severity of the disease were similar in the 2 groups. After 2, 4, 6, and 8 . . . [Full Text of this Article] Results
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