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Cicatricial pemphigoid (CP) is a variant of pemphigoid and is described as a chronic autoimmune bullous disease characterized by subepithelial blistering of mucous membranes with or without skin involvement. Clinical manifestations include characteristic scarring; oral, nasal, and vaginal mucous membrane lesions; erosive stomatitis; gingivitis; and ocular scarring. The usual presentation occurs in the fifth or sixth decade of life. Treatment regimens include systemic corticosteroids and immunosuppressive agents, including azathioprine and cyclophosphamide used in rapidly advancing disease states.¹

Little is known about the etiology or pathogenesis of CP.¹ Some triggering event may lead to the development of autoantibodies against one of several target epithelial basement membrane antigens.^2-3 These antigens include bullous pemphigoid antigen II (180 kd), laminin type 5, and 4 integrin.^3-4 The events initiating this autoimmune mechanism are still a topic of research. We report a case in which, during azathioprine therapy, a patient with a history of CP experienced . . . [Full Text of this Article]

Report of a Case


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