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Primary acquired melanosis is characterized by hyperpigmented, macular lesions of the conjunctival epithelium.¹ Many of these lesions may progress to melanoma, thus necessitating early diagnosis and management.² Lentigo maligna refers to indolent melanoma in situ that occurs on sun-exposed areas of the head and neck.³ Treatment options have included excisional surgery, Mohs surgery, cryosurgery, and ruby laser surgery.^4-10 Melanoma in situ of the eyelid represents a therapeutic challenge because of the need to balance tissue conservation with full clearance of the tumor and to reduce rates of recurrence and progression to invasive melanoma.^11-12 We report the successful treatment of lentigo maligna of the eyelid in a patient with primary acquired melanosis using intralesional interferon alfa.

A 58-year-old man with multiply recurrent melanoma of the eyelid in situ and primary acquired melanosis was referred to us for evaluation of hyperpigmented lesions on the upper and lower eyelids that were consistent with . . . [Full Text of this Article]