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Granulomatous Cheilitis, Melkersson-Rosenthal Syndrome, and Orofacial Granulomatosis
Arch Dermatol. 2000;136:1557-1558.
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IN THIS issue of the ARCHIVES, Muellegger et al1 focus our attention on chronic granulomatous diseases and the microorganism Borrelia burgdorferi as a possible infectious cause of the granulomatous cheilitis (GC) of Miescher,2 Melkersson-Rosenthal syndrome (MRS),3 and orofacial granulomatosis (OFG).4
Granulomatous cheilitis is a variant of MRS,3, 5 which is associated with a peripheral facial palsy that is indistinguishable from Bell palsy. Lyme borreliosis, a multisystem disease caused by the B burgdorferi spirochete, is also associated with a peripheral facial palsy. Muellegger and colleagues1 sought evidence of B burgdorferi–specific DNA by polymerase chain reaction in tissue samples from 12 patients with GC/MRS to determine if a causal relationship was present. All patients resided in areas endemic for Lyme borreliosis in Austria. No such association was identified in these 12 patients.
WHAT ARE THESE GRANULOMATOUS CONDITIONS?
In 1928, Melkersson6 described a 35-year-old woman with facial edema and paralysis and suggested that there was a relationship between . . . [Full Text of this Article]
WHAT DOES DRIVE THE GRANULOMATOUS TISSUE RESPONSE OF MRS, GC, AND OFG?
RELATED ARTICLE
Granulomatous Cheilitis and Borrelia burgdorferi: Polymerase Chain Reaction and Serologic Studies in a Retrospective Case Series of 12 Patients
Robert R. Muellegger, Wolfgang Weger, Natalie Zoechling, Steven Kaddu, H. Peter Soyer, Laila El Shabrawi-Caelen, and Helmut Kerl
Arch Dermatol. 2000;136(12):1502-1506.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Chronic Periorbital Swelling in an Elderly Man--Diagnosis
Arch Dermatol 2003;139:1075-1080.
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