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Truncal Hypopigmented Macules and Facial Hyperpigmented Papules
L. R. Whittam, MRCP;
D. M. MacDonald, FRCP;
E. Calonje;
J. Breuer, MD, MRCPath;
P. Spink;
J. N. W. N. Barker, FRCP
St John's Institute of Dermatology, St Thomas' Hospital (Drs Whittam, MacDonald, and Barker and Mr Calonje), and the Virology Clinical Group, Royal London Hospital (Dr Breuer and Mr Spink), London, England
Arch Dermatol. 2000;136:259-264.
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REPORT OF A CASE
A 36-year-old native Nigerian woman presented with a 20-year history of persistent and progressive skin lesions. There was no relevant family or personal history. Physical examination revealed hypopigmented macules with irregular borders on the patient's trunk (Figure 1) and hyperpigmented scaly papules on her face and neck (Figure 2). The physical examination findings were otherwise normal. A skin biopsy specimen was obtained from the trunk (Figure 3) and from a papule on the face (Figure 4).
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Figure 1.
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Figure 2.
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Figure 3.
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Figure 4.
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What is your diagnosis?
Diagnosis: Epidermodysplasia verruciformis (EDV).
Histologic examination of the specimen from the trunk revealed enlarged keratinocytes with lightly basophilic cytoplasm. Examination of the facial papule specimen revealed keratinocytes with perinuclear vacuolation as well as enlarged and atypical . . . [Full Text of this Article]
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