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The Importance of Histological Step Sections (and Other Factors)

Arch Dermatol. 2000;136:535-537.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of the ARCHIVES, Carag et al¹ provide objective evidence in support of obtaining additional, so-called step or deeper sections when a diagnosis of actinic keratosis (AK) is rendered on microscopic examination of routine histological sections. In their study, they produced 10 additional slides taken at 50-µm intervals in each of 69 consecutive AKs diagnosed on initial sections. By this unusually thorough protocol, they identified additional histopathological changes that resulted in modified diagnoses in one third of specimens. Although not all of the newly discovered lesions were clinically significant, approximately 20% of the specimens revealed fully evolved, malignant keratinocytic neoplasms: squamous cell carcinoma (SCC) or basal cell carcinoma. Furthermore, a majority of the carcinomas identified in this study required more than 5 step sections. Although most of the newly discovered neoplasms were basal cell carcinomas or SCCs in situ, 2 were SCCs involving the dermis, therefore possessing the . . . [Full Text of this Article]

WHEN TISSUE CONTAINING PATHOLOGICAL CHANGES REMAINS IN THE PARAFFIN BLOCK


WHEN THE DIAGNOSTIC TISSUE IS NOT PRESENT IN THE PARAFFIN BLOCK

THE IMPORTANCE OF CLINICOPATHOLOGICAL CORRELATION

CONCLUSIONS


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RELATED ARTICLE

Utility of Step Sections: Demonstration of Additional Pathological Findings in Biopsy Samples Initially Diagnosed as Actinic Keratosis
Henry R. Carag, Victor G. Prieto, Liza S. Yballe, and Christopher R. Shea
Arch Dermatol. 2000;136(4):471-475.
ABSTRACT | FULL TEXT