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  Vol. 136 No. 5, May 2000 TABLE OF CONTENTS
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Allogenic Keratinocytes Suspended in Human Fibrin Glue Used for Wound Healing Support in Chronic Leg Ulcers

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Wound healing is a complex biological process. The imbalance in growth factors, cytokines, and matrix metalloproteinases in wounds promotes the establishment and maintenance of chronic wounds. We are introducing a new method for the treatment of chronic wounds using allogenic keratinocytes suspended in human fibrin glue for the stimulation of granulation and reepithelialization.

Report of a Case

We describe a 76-year-old woman with an arteriovenous ulcer extending to the entire lower leg. Surgical treatment with a femoropopliteal bypass improved the arterial situation but showed no effect on wound healing. Despite intensive wound care, including surgical and enzymatic debridement, hydrocolloid dressings, and compression therapy, there was no development of fresh granulation tissue and no tendency of reepithelialization within 1 year (Figure 1).


 
Figure appears in full text version.
Figure 1. Arteriovenous ulcer of the lower leg without development of fresh granulation tissue and with no tendency of reepithelialization within 1 year.


For this reason we started the following treatment. . . . [Full Text of this Article]


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