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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In our opinion, the tested regimens for the use of current antifungals in the treatment of onychomycosis^1-5 are not optimal for the clinical use of these drugs and also are misleading with respect to efficacy. A flurry of letters in the literature indicates that our concerns are shared.^6-7

There is a difference of opinion about whether orally administered drug enters the nail bed and overlying nail plate through the entire area of the nail bed or is incorporated into these structures in their individual matrix regions and then moves distally. In either case, however, the assumption that the nail bed maintains fungistatic or fungicidal properties after a fixed period of treatment that is shorter than the time required to replace the entire toenail by normal growth has not been demonstrated in these large studies.

In our own office practice, we treated 20 consecutive patients with total nail bed culture positive . . . [Full Text of this Article]

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The Successful Treatment of Trichophyton rubrum Nail Bed (Distal Subungual) Onychomycosis With Intermittent Pulse-Dosed Terbinafine
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Arch Dermatol 2004;140:691-695.
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Treatment of Dermatophyte Toenail Onychomycosis in the United States: A Pharmacoeconomic Analysis
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Intermittent Terbinafine for Toenail Onychomycosis: Is It Effective? Results of a Randomized Pilot Trial
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Arch Dermatol 2001;137:1253-1253.
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