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Cutaneous T-Cell Lymphomas—How and Why Should They Be Recognized?

Arch Dermatol. 2000;136:1052-1054.

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IN THIS issue of the ARCHIVES, Toro and coworkers¹ report the clinicopathologic features of 3 adult male patients with cutaneous T-cell lymphomas (CTCLs) involving the skin. These patients were distinguished by multiple plaques, tumors, and subcutaneous nodules distributed over their extremities. The lesions showed histologic evidence of epidermotropism, dermal and subcutaneous infiltration by atypical lymphocytes without cerebriform nuclei. The tumor cells had a distinct immunophenotype expressing the T-cell receptor (TCR) heterodimer instead of the more common TCR heterodimer. In addition, the tumor cells had a cytotoxic profile, expressing T-cell intracellular antigen 1 (TIA-1), granzyme B, and perforin. Importantly, all 3 patients with CTCL had an aggressive clinical course with resistance to various chemotherapies. Similar results have been reported in the literature for patients with this uncommon type of lymphoma.^2-5

Because of its poor prognosis and resistance to chemotherapy and radiation, it is important to distinguish CTCLs from mycosis fungoides (MF) . . . [Full Text of this Article]

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RELATED ARTICLE

T-Cell Lymphoma of the Skin: A Clinical, Microscopic, and Molecular Study
Jorge R. Toro, Micheal Beaty, Lynn Sorbara, Maria L. Turner, Jeffrey White, Douglas W. Kingma, Mark Raffeld, and Elaine S. Jaffe
Arch Dermatol. 2000;136(8):1024-1032.
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