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Recalcitrant facial erythema often occurs in adults with atopic dermatitis and resists common therapies, including topical corticosteroids.¹ Recently, several authors have reported that short-term use of tacrolimus (FK506) ointment, a newly developed immunosuppressant drug, shows excellent results with recalcitrant facial erythema.^2-5 In the present study, we analyzed the effects of long-term applications of topical tacrolimus on red face conditions.

Patients and Methods

After obtaining informed consent, 51 adult patients (age range,16-44 years) with atopic dermatitis, who had steroid-resistant diffuse indurated erythema on the face for 1 to 23 years (average, 5 years), were included in the study. All fulfilled Hanifin and Rajka's diagnostic criteria⁶ for atopic dermatitis. Active skin lesions on the trunk and limbs were present on less than 10% of the total body surface in 27 patients, 10% to 50% of the body surface in 10 patients, and more than 50% of the body surface in 14 patients.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Topical Tacrolimus
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Arch Dermatol 2005;141:1468-1468.
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