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Curly Hair and Lipodystrophy as a Result of Highly Active Antiretroviral Treatment?
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Different hair changes have been reported during human immunodeficiency virus infection. In patients with acquired immunodeficiency syndrome, hair may become softer, silky, discolored, and less curled.1 We recently observed a patient with acquired immunodeficiency syndrome whose previously straight hair became curly during highly active antiretroviral treatment (HAART) about 4 months before developing a spinocellular epithelioma.
Case Report
A 48-year-old Belgian heterosexual truck driver was diagnosed with human immunodeficiency virus infection in 1991. His medical history revealed polyallergic asthma since childhood. In February 1993, his CD4 lymphocyte count was 130/µL and zidovudine monotherapy was started; in 1995, didanosine was added to his regimen. In October 1995, he developed severe pulmonary tuberculosis, complicated by adrenal insufficiency. He recovered after taking tuberculostatica with glucocorticoid and mineralocorticoid substitution.
In September 1996, HAART was initiated, including lamivudine, stavudine, and indinavir (a protease inhibitor). The glucocorticoid and mineralocorticoid substitution was continued. In February 1998, he noted that his . . . [Full Text of this Article]
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