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Topical Cidofovir
A Novel Treatment for Recalcitrant Molluscum Contagiosum in Children Infected With Human Immunodeficiency Virus 1
Jorge R. Toro, MD;
Lauren V. Wood, MD;
Nitin K. Patel, RPh;
Maria L. Turner, MD
From the Dermatology Branch (Drs Toro and Turner), HIV and AIDS Malignancy Branch (Dr Wood), and Clinical Center Pharmacy Department (Mr Patel), National Cancer Institute, National Institutes of Health, Bethesda, Md.
Arch Dermatol. 2000;136:983-985.
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REPORT OF CASES
Two children with human immunodeficiency virus 1 (HIV-1) presented to the dermatology clinic for treatment of disseminated molluscum contagiosum (MC). Both children suffered from severe social isolation because of their facial disfigurement. Their MC lesions were refractory to numerous therapeutic modalities, including liquid nitrogen, cantharidin, and 0.05 % tretinoin gel. Both children had MC lesions, elevated viral loads, and low CD4 T-cell counts despite highly active antiretroviral therapy (HAART) for a median of 24 months. Patient 1, an 8-year-old African American boy, had a CD4 T-cell count of 329/µL and a viral load of 727,050 (log 5.86) HIV RNA copies/mL. Patient 2, a 4-year-old-Hispanic boy, had a CD4 T-cell count of 168/µL and a viral load of 429,976 (log 5.63) HIV RNA copies/mL
Both patients exhibited hundreds of umbilicated pearly and skin-colored papules disseminated . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
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