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Arch Dermatol. 2000;136:1142-1143.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers
Dale JJ, Ruckley CV, Harper DR, Gibson B, Nelson EA, Prescott RJ
BMJ. 1999;319:875-878.

The objective of this study was to determine if pentoxifylline, 400 mg, taken orally 3 times a day as an adjunct therapy to ambulatory limb compression bandages to treat venous leg ulcer was more efficacious than ambulatory limb compression bandages with a matching placebo by 24 weeks of care. Previous clinical trials had produced conflicting results.

The reported trial was part of a double-masked, randomized clinical trial that evaluated both pentoxifylline and different types of limb and ulcer bandages. For an efficient trial, a factorial design was used. A trial has a factorial design when 2 or more interventions are evaluated separately, in combination, and against a control. The study was conducted at 2 different study sites. The study population . . . [Full Text of this Article]

Editor's Comment

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Should Pentoxifylline Be Used as an Adjuvant for the Treatment of Venous Leg Ulcer?
Margolis
Arch Dermatol 2002;138:1597-1598.
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