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Pruritic Vulvar Nodule in a Black Woman
Ricardo F. de Misa, MD;
Victoria Castro, MD;
José Suárez, MD;
Antonio Perera, MD
Complejo Hospitalario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
Arch Dermatol. 2000;136:1165-1170.
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REPORT OF A CASE
A 35-year-old black woman presented with a pruritic nodule in the vulvar region. Over the last 3 years, the lesion had progressively enlarged. The patient's medical history was otherwise unremarkable. Physical examination revealed a 1.5 x 0.8 x 0.4-cm, brown, oval nodule with a mildly scaly surface and well-defined borders, located at the left labium majus (Figure 1). The lesion was well circumscribed, nontender, elastic, and freely mobile. The lesion was surgically excised (Figure 2).
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Figure 1.
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Figure 2.
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What is your diagnosis?
Diagnosis: Granular cell tumor (Abrikossoff tumor).
Hematoxylin-eosin staining revealed a nonencapsulated nodule involving the entire dermis, with some extension into the subcutis, and an overlying epidermis with moderate pseudoepitheliomatous hyperplasia. The neoplasm was composed of large, plump, polyhedral cells with granular eosinophilic cytoplasm. The cells were clustered as nests, with collagen bundles surrounding some of . . . [Full Text of this Article]
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