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Minocycline, a semisynthetic derivative of tetracycline, has become a frequently prescribed medication for the treatment of nodulocystic acne and of persistent acne not responding to tetracycline as its first line of management. It has been associated with serious adverse events, eg, hyperpigmentation of various tissues, autoimmune disorders (systemic lupus erythematosus, autoimmune hepatitis), and serious hypersensitivity reactions (hypersensitivity syndrome reaction, pneumonitis and eosinophilia, and serum sickness).¹ Among these, the number of cases of serum sickness reported in the literature is small in relation to the number of prescriptions of minocycline. However, it is very important that prescribing physicians be aware of the possibility of these uncommon events so that they can recognize the characteristic symptoms at an early stage. Recently, we came across 2 cases of serum sickness after minocycline therapy for severe acne. We herein describe these 2 events.

Report of Cases

Case 1

A 16-year-old girl being treated with minocycline for nodulocystic acne developed . . . [Full Text of this Article]

Case 2

Comment

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

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NEJM 2006;354:601-609.
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