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Imiquimod and 5% Fluorouracil Therapy for Anal and Perianal Squamous Cell Carcinoma In Situ in an HIV-1–Positive Man
MAJ James Pehoushek, MC, USA;
COL Kathleen J. Smith, MC, USA
From the National Naval Medical Center, Bethesda, Md.
Arch Dermatol. 2001;137:14-16.
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REPORT OF A CASE
A 59-year-old human immunodeficiency virus-1–positive (HIV-1+) white man presented with a nonhealing area that extended extensively around the perianal skin and up into the anal canal. The area had been present for greater than 2 years with an increase in size over the past 6 months. Biopsies were performed, and multiple biopsy specimens sampled from the cutaneous surface as well as within the distal anal canal showed squamous cell carcinoma in situ.
The patient's HIV-1 disease had been diagnosed approximately 15 years earlier, and had been well controlled during most of that time with antiviral therapy, including protease inhibitors over the past 4 years. The patient's CD4 cell count was more than 500/µL, and he had an unmeasurable viral load; he had been taking stavudine (40 mg twice daily), lamivudine (150 mg twice daily), indinavir (400 mg twice daily), . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
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ABSTRACT
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ABSTRACT
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