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Failure of Benzathine Penicillin in a Case of Seronegative Secondary Syphilis in a Patient With Acquired Immunodeficiency Syndrome: Case Report and Review of the Literature
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We report a case of secondary syphilis in a patient with human immunodeficiency virus (HIV) and negative serologic test findings who did not respond to initial therapy with benzathine penicillin. A skin biopsy specimen prepared with Warthin-Starry stain revealed spirochetes and led to the appropriate treatment and resolution of symptoms.
Report of a Case
A 39-year-old black woman presented to the infectious diseases clinic with a 3- to 4-week history of a painless, pruritic eruption that had begun in her perianal area and extended anteriorly onto her vulva. The patient had been diagnosed with HIV in 1996; her most recent CD4 count and HIV RNA viral load were 81 x 106/L and 191 000 copies/mL, respectively. She acknowledged poor adherence to her antiretroviral medication regimen.
Physical examination findings were remarkable for 2- to 3-mm split papules bilaterally in the oral commissures; indistinct, hyperpigmented, scaly patches on the back, abdomen, and legs; and confluent, flat-topped, . . . [Full Text of this Article] Comment
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Latent Syphilis Confirmed by Polymerase Chain Reaction in 2 HIV-Positive Patients With Inconclusive Serologic Test Results
Kuznetsov et al.
Arch Dermatol 2005;141:1169-1170.
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