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A Global Perspective

Alisa M. Goldstein, PhD; Margaret A. Tucker, MD

Arch Dermatol. 2001;137:1493-1496.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Cutaneous malignant melanoma (CMM) results from the interaction of genetic, host, and environmental influences. Epidemiologic studies of melanoma have shown that the major environmental risk factor is UV radiation. The exposure-response relationship, however, seems complex, with intermittent sun exposure likely to be more important for risk than total lifetime exposure (for a review, see Armstrong and English¹). The host factors most strongly associated with melanoma are melanocytic nevi (moles), both clinically banal and atypical (dysplastic).^1-2 Other host factors implicated in melanoma include fair hair color, light eye color, increased freckling, and an inability to tan. Nonmelanoma skin cancer (basal cell or squamous cell carcinoma) also increases the risk for melanoma.¹

Approximately 5% to 12% of malignant melanomas develop in individuals who have 1 or more first-degree relatives with CMM.³ Such clustering is denoted familial melanoma. No precise definition exists for the . . . [Full Text of this Article]

MELANOMA PREDISPOSITION GENES

CDKN2A

CDKN2A: FUTURE STUDIES

FUTURE GENETIC EPIDEMIOLOGIC RESEARCH

MUTATION TESTING

CONCLUSIONS

From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md.

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