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Genomic Approaches to Skin Cancer Diagnosis
Boris C. Bastian, MD;
Philip E. LeBoit, MD;
Dan Pinkel, PhD
Arch Dermatol. 2001;137:1507-1511.
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INTRODUCTION
Dermatopathologic analysis is the gold standard for the diagnosis of skin cancer. It is an accurate and cost-efficient method for classification of most cutaneous neoplasms. However, despite constantly refined morphological criteria, there remain areas in which histopathologic analysis does not permit an unequivocal diagnosis. Among these, lymphoproliferative and melanocytic lesions present the most frequent diagnostic problems. The predicaments of less-than-optimal agreement between observers and misdiagnosis of these disorders are well documented.1-7 Failure to recognize melanoma, as well as lymphoma, leads the list of malpractice claims among general pathologists, let alone dermatopathologists.8 The advent of therapeutic interventions for melanoma, some of which have serious adverse effects, makes the need for accurate, early diagnosis more important than ever.
Cancer is a genetic disease (ie, it is a disease of the genome), but not necessarily a hereditary one. Using genomic approaches for . . . [Full Text of this Article]
ANALYSIS OF GENOMIC DNA
Karyotyping Allelic Imbalance Fluorescence In Situ Hybridization Comparative Genomic Hybridization
ANALYSIS OF RNA
CONCLUSIONS
From the Departments of Dermatology and Pathology and the Comprehensive Cancer Center, University of California, San Francisco.
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