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Primary cutaneous large B-cell lymphoma (PCLBCL) of the leg is a recently recognized distinct type of B-cell neoplasm that has an intermediate prognosis.^1-5 Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive, usually fatal disease that often involves the skin and central nervous system (CNS).^2-4 Primary cutaneous forms of IVLBCL are thought to have a more favorable prognosis.^2-3 We describe the first reported case of PCLBCL of the leg relapsing initially as a cutaneous IVLBCL and then occurring in the CNS.

Report of a Case

In November 1995, a 61-year-old healthy white woman presented with a 1-year history of red nodules on her left lower leg. A biopsy specimen was interpreted elsewhere as cutaneous lymphoid hyperplasia, and the nodules resolved with topical steroids. In August 1997, examination of the skin revealed new violaceous nodules and erythematous patches on the left lower leg (Figure 1). Findings of histologic analysis showed a deep, dense, . . . [Full Text of this Article]

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