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Low-Dose Interferon Alfa-2b for the Treatment of Churg-Strauss Syndrome With Prominent Skin Involvement
Christian C. Termeer, MD;
Jan C. Simon, MD;
Erwin Schöpf, MD
Arch Dermatol. 2001;137:136-138.
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REPORT OF A CASE
A 68-year-old man presented with a medical history of recurrent bronchial asthma and sinusitis maxillaris. He had a severe bronchial infection that was treated with a combination product of sulfamethoxazole and trimethoprim and subsequently with cefadroxil in combination with low-dose (20 mg/d of prednisolone) therapy for treatment of the asthma. Three weeks after discontinuation of of antibiotic therapy but continuation of use of prednisolone, 20 mg/d, he developed severe bronchial asthma, sinusitis, systemic hypereosinophilia, and characteristic granulomatous skin lesions on the upper half of the back, in the axilla and inguinal region, rapidly expanding within days (Figure 1A). Skin lesions consisted of sharply marginated, erythematous plaques of dull red with a central clearing and a centrifugal spread (Figure 1A). The patient reported occasional mild pruritus. The presumptive diagnosis of Churg-Strauss syndrome (CSS) was confirmed by . . . [Full Text of this Article]
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