This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In an interesting article "Response of Murine and Normal Human Skin to Injection of Allogeneic Blood-Derived Psoriatic Immunocytes," Nickoloff et al¹ present an innovative idea that immunocytes expressing receptors of natural killer (NK) cells play a possible role in the pathogenesis of psoriasis. The authors suggest that the inhibitory receptors on NK cells (killer cell inhibitory receptors [KIRs]) may prevent NK T-cell–induced lysis of self major histocompatibility complex (MHC) class I–bearing target cells while killer cell activating–receptors (KARs) may activate NK T-cell cytotoxicity and probably contribute to the damage of the epidermal basement membrane in the early stages of disease.

The recognition of a possible involvement of KIRs and KARs in the immune pathogenesis of psoriasis is of great interest. Inhibitory receptors, always predominating over the activating ones,² inhibit T-cell–mediated functions, thus reducing T-cell responses. Importantly, some inhibitory receptors (eg, p58) are specific for HLA-C, and HLA-Cw6 is believed to . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Psoriasis and the new biologic agents: interrupting a T-AP dance
Walsh and Shear
CMAJ 2004;170:1933-1941.
ABSTRACT | FULL TEXT