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Neurofibromatosis type 1 (NF1) develops various neurocutaneous manifestations in patients at various ages.¹ It has been suggested that Lisch nodules or pigmented iris hamartomas appear in infancy or early childhood²; however, the frequency of their appearance has been reported to range from 56% to 97% in patients with NF1; there is great discrepancy among these reports.^3-4 Since Lisch nodules are usually asymptomatic, little information is available on their clinical behavior.

In the present study, patients with NF1 were examined over an 11-year period for both ophthalmological and dermatological abnormalities. The characteristics of Lisch nodules as well as their correlation with NF1 skin manifestations of café au lait spots and cutaneous neurofibroma are reported herein.

Patients and Methods

Seventy patients with NF1(average age, 22 years; age range, 3 months to 79 years) were first dermatologically examined and then ophthalmologically examined using slitlamp biomicroscopy. For 20 patients (average age, 10.5 years), serial multiple ophthalmological . . . [Full Text of this Article]

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