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  Vol. 137 No. 3, March 2001 TABLE OF CONTENTS
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  Evidence-Based Dermatology: Research Commentary
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Challenges to the Hierarchy of Evidence: Does the Emperor Have No Clothes?

Arch Dermatol. 2001;137:345-346.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A Comparison of Observational Studies and Randomized, Controlled Trials
Benson K and Hartz AJ
N Engl J Med. 2000;342:1878-1786
Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Design
Concato J, Shah N, and Horwitz RI
N Engl J Med. 2000;342:1887-1892

An important tenet of evidence-based medicine is that there is a hierarchy of evidence. For studies of therapy, in descending order, this hierarchy consists of meta-analyses of randomized clinical trials, randomized controlled clinical trials with narrow confidence intervals, cohort studies, case-control studies, large case series, expert opinion, and in vitro and animal studies. It has been claimed that observational studies find stronger treatment effects than randomized controlled trials. Two recent studies published in the New England Journal of Medicine challenge the veracity of this tenet.1-2

Benson and Hartz1 compared the results of observational studies of the treatment of several diseases with those of randomized controlled trials of . . . [Full Text of this Article]

Editor's Comment



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Evidence, hierarchies, and typologies: horses for courses
Petticrew and Roberts
J. Epidemiol. Community Health 2003;57:527-529.
ABSTRACT | FULL TEXT  





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