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Cyclosporine Therapy Should Be Considered for Maintenance of Remission in Patients With Pemphigus
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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In a randomized trial published in the July issue of ARCHIVES, Ioannides1 et al compared the effectiveness of corticosteroids alone with a combination of corticosteroids and cyclosporine in 33 hospitalized patients with pemphigus. The authors clearly demonstrated that adding cyclosporine to a corticosteroid treatment regimen had no advantage over corticosteroids alone in the acute phase of the disease.
The effect of cyclosporine as adjuvant therapy in patients with pemphigus has been studied previously2-8 with conflicting results, some of which point quite convincingly to a positive effect. We wish to argue that cyclosporine may still have an important role as adjuvant therapy in maintaining remission during the long-term follow-up of nonhospitalized patients with pemphigus. As an example, one of our patients, a 38-year-old man treated on an ambulatory basis, was diagnosed with pemphigus vulgaris based on characteristic clinical, histologic, and immunofluorescent features. Remission was achieved using corticosteroids alone.
A relapse of . . . [Full Text of this Article]
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