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Mycosis Fungoides Evolves From Reactive Inflammatory Conditions (Lymphoid Infiltrates) Transforming Into Neoplastic Plaques and Tumors

Arch Dermatol. 2001;137:949-952.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ARTICLE by Rubegni et al¹ describes the cytokine production profile of peripheral blood mononuclear cells (PBMCs) in patients with large-plaque parapsoriasis. Interleukin 4 (IL-4) and interferon gamma (IFN-) were measured in PBMCs following phytohemagglutinin antigen (PHA) stimulation in patients with large-plaque parapsoriasis (LPP), patients with stage Ib (more than 10% of the body surface involved) mycosis fungoides (MF), and healthy controls. One difficulty with this approach is the bias in differentiating LPP and early patch-stage MF. As acknowledged by the authors,¹ discrimination between the 2 diseases emerges as increasingly difficult. It is not clear why 4 patients (40% in their series of patients with LPP, Nos. 4, 5, 8, and 9) whose cells exhibited T-cell receptor gamma (TCR-) rearrangement were included in the LPP group instead of with the early MF group. Furthermore, the question raised is how many of the patients diagnosed as having early MF . . . [Full Text of this Article]

DEFINITIONS: INFLAMMATION VS NEOPLASIA


PRENEOPLASTIC CONDITIONS AND PPP DO NOT EXHIBIT DIAGNOSTIC CRITERIA OF MF

THE PATHOGENESIS OF CUTANEOUS LYMPHOMAS: WHEN DOES MF START?

CYTOGENETIC STUDIES SUPPORT THE CONCEPT OF A MULTISTEP EVOLUTION OF CTCL

CONCLUSIONS


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