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Melody Vander Straten, MD; Daniel Carrasco, MD; Patricia Lee, MD; Stephen K. Tyring, MD, PhD

Arch Dermatol. 2001;137:1232-1235.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

The study by McKeough and Spruance¹ in this issue of the ARCHIVES demonstrates the relative efficacy of 4 topical antiviral agents for the treatment of herpes simplex virus type 1 (HSV-1) infection using the backs of guinea pigs. Efficacy was measured by reductions in lesion number, area, and virus titer. They found, in this model, that the relative efficacy of penciclovir cream was greater than acyclovir cream, acyclovir cream was greater than or equal to acyclovir ointment, and acyclovir ointment was greater than n-docosanol cream. A clinical study comparing all 4 agents would be very expensive and is unlikely ever to be done. The authors note, however, that the guinea pig model is twice as sensitive to antiviral therapies as is herpes labialis. It is therefore interesting that the relative efficacies in the animal model . . . [Full Text of this Article]

TRANSMISSION AND PATHOGENESIS

CLINICAL MANIFESTATIONS

ANTIVIRAL THERAPY

CONCLUSIONS

From the Departments of Microbiology/Immunology (Drs Vander Straten, Carrasco, Lee, and Tyring), Dermatology (Dr Tyring), and Internal Medicine (Drs Straten, Carrasco, Lee, and Tyring), University of Texas Medical Branch, Galveston.

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